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Gottfried Treviranus Facharzt FMH
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IRBD 2011 Brain architecture & K. Askland's biaxial model

This poster was shown at the IRBD 2011 conference in Rome. It deals with predictions derived by crossing the biaxial model of K. Askland for bipolar disorder with the neurobiological anatomic interpretation of the THOUGHT-ACTION-MOOD-model. A general stronger dependance of frontal symbolic and mesocephalic incentive appetite ("THOUGHT") from receptors and transmitters is opposed by a stronger dependance of the "parietal movement brain" (ACTION/INTUITION) from ion channels - and their relative genes.

You can easily navigate the poster in the following "prezi" (click!).



The central hypotheses fueling the research of Kathleen Askland more generally are that:

a) shared and disease-specific genetic susceptibility to several neuropsychiatric disorders, at the population-level, is mediated by disruption of genes characterized by one or a limited combination of shared and discernible biological attributes, and

b) the genetic architecture of these complex disorders is characterized by substantial inter-individual genetic heterogeneity.

The hypothesis has been formulated on the basis of previous studies in complex genetic disorders, results and inconsistencies of previous neuropsychiatric research, as well as our own preliminary data. The rationale for the proposed research is that, first, uncovering the particular biological attributes defining susceptibility genes is likely to be of much greater significance to our understanding of disease and to future discovery efforts than any current single marker finding.

Second, discovering the nature of the complex genetic architecture will inform valid models of genetic transmission and refinements of phenotypes upon which the design of future studies can be based. In so doing, it will also test the validity of the guiding assumptions about genetic risk in current neuropsychiatric genetic research. And third, together these results will make possible more targeted resequencing, fine-mapping and functional studies to uncover both the common and rare, as yet elusive, functional variants. SOURCE (click!)